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Nucleosidic DNA demethylating epigenetic drugs – A comprehensive review from discovery to clinic

15 Feb 2018

Abstract excerpt

DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic silencing of cancer-related genes. Since the relationship between aberrant DNA methylation and cancer has been understood, there has been an explosion of research at developing anti-cancer therapies that work by inhibiting DNA methylation. From the discovery of first DNA hypomethylating drugs in the 1980s to recently discovered...

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PMID: 29454856
DOI: 10.1016/j.pharmthera.2018.02.006

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