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Article

Inhibiting translation elongation can aid genome duplication in Escherichia coli.

Nucleic acids research - 17 Mar 2017

Myka Kamila K, Hawkins Michelle, Syeda Aisha H, Gupta Milind K, Meharg Caroline, Dillingham Mark S, Savery Nigel J, Lloyd Robert G, McGlynn Peter

Abstract excerpt

Conflicts between replication and transcription challenge chromosome duplication. Escherichia coli replisome movement along transcribed DNA is promoted by Rep and UvrD accessory helicases with Δrep ΔuvrD cells being inviable under rapid growth conditions. We have discovered that mutations in a tRNA gene, aspT, in an aminoacyl tRNA synthetase, AspRS, and in a translation factor needed for efficient proline-proline...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Peptide Chain Elongation, Translational

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Source

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Identifiers

PMID: 27956500
DOI: 10.1093/nar/gkw1254
PMCID: PMC5389703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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