Article

Structural Basis for Retron Co-option of Anti-phage ATPase-nuclease

2025-05-11

Abstract excerpt

<h4>Summary</h4> Retrons are recently identified bacterial defense systems that employ a tripartite of reverse transcriptase, non-coding RNA (ncRNA) and its derived multi-copy single stranded DNA (msDNA) to sequester effector activity. Phage invasion activates retrons, triggering effector activity and inducing abortive infection and cell growth arrest. Ec78 distinguishes itself from other retrons by leveraging th...

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Literature Corpus work: 125e02ec-c952-5128-8807-7bd75901a8bd
DOI: 10.1101/2025.05.10.653283

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