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Article

Genetic and biochemical interactions between the bacterial replication initiator DnaA and the nucleoid-associated protein Rok in Bacillus subtilis.

Molecular microbiology - 1 Mar 2017

Seid Charlotte A, Smith Janet L, Grossman Alan D

Abstract excerpt

We identified interactions between the conserved bacterial replication initiator and transcription factor DnaA and the nucleoid-associated protein Rok of Bacillus subtilis. DnaA binds directly to clusters of DnaA boxes at the origin of replication and elsewhere, including the promoters of several DnaA-regulated genes. Rok, an analog of H-NS from gamma-proteobacteria that affects chromosome architecture and of...

Topics

Bacillus subtilis
Bacterial Proteins
DNA Replication
DNA, Bacterial
DNA-Binding Proteins
Gene Expression
Gene Expression Regulation, Bacterial
High-Throughput Nucleotide Sequencing
Mutation
Operon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Replication Origin

Transcription, Genetic

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Identifiers

PMID: 27902860
DOI: 10.1111/mmi.13590
PMCID: PMC5323315

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