Article

The TIM22 complex regulates mitochondrial one-carbon metabolism by mediating the import of Sideroflexins

2020-02-07

Abstract excerpt

The Acylglycerol Kinase (AGK) is a mitochondrial lipid kinase that contributes to protein biogenesis as a subunit of the TIM22 complex at the inner mitochondrial membrane. Mutations in AGK cause Sengers syndrome, an autosomal recessive condition characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy and lactic acidosis. We undertook proteomic profiling of Sengers patient fibroblasts...

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Literature Corpus work: 2d2e4a87-99b0-5e04-b207-3477e34034ee
DOI: 10.1101/2020.02.06.937920

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