Article

Microbial transglutaminases generate T cell stimulatory epitopes involved in celiac disease

2008-03-01

Abstract excerpt

Celiac disease (CD) is a permanent intolerance to gluten. In CD patients, gluten peptides cause an inflammation in the small intestine leading to tissue damage. Tissue transglutaminase (tTG) is an enzyme involved in the repair of damaged tissue by crosslinking of extracellular matrix proteins. Under certain conditions, tTG can deamidate glutamine into glutamic acid. Compared to native gluten, deamidated gluten eli...

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Identifiers and source

Literature Corpus work: b66f8ed0-7dac-5566-bdf2-6188cb233eef
DOI: 10.1016/j.jcs.2007.05.004

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