Article
Gluten: a two-edged sword. Immunopathogenesis of celiac disease.
Springer seminars in immunopathology - 1 Sept 2005
Koning Frits, Gilissen Luud, Wijmenga Cisca
Abstract excerpt
Celiac disease (CD) is a small intestinal disorder caused by adaptive and innate immune responses triggered by the gluten proteins present in wheat. In the intestine, gluten is partially degraded and modified, which results in gluten peptides that bind with high affinity to HLA-DQ2 or HLA-DQ8 and trigger an inflammatory T cell response. Simultaneously, gluten exposure leads to increased production of IL15, which...
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