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Article

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.

Nature cell biology - 1 May 2015

Ditadi Andrea, Sturgeon Christopher M, Tober Joanna, Awong Geneve, Kennedy Marion, Yzaguirre Amanda D, Azzola Lisa, Ng Elizabeth S, Stanley Edouard G, French Deborah L, Cheng Xin, Gadue Paul, Speck Nancy A, Elefanty Andrew G, Keller Gordon

Abstract excerpt

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the early embryo, HSCs develop from the haemogenic endothelium (HE) and are specified in a Notch-dependent manner through a process named endothelial-to-haematopoietic transition (EHT). As HE is associated with arteries, it is assumed that it...

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Identifiers

PMID: 25915127
DOI: 10.1038/ncb3161
PMCID: PMC4551438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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