Article

Cardiomyocyte-intrinsic SLC25A1 regulates cardiac differentiation and mitochondrial function

2026-03-10

Abstract excerpt

Cardiac morphogenesis is an intricate process that requires a precise coordination between metabolic and structural maturation, but how these processes are linked remain unclear. In previous work, we identified one candidate underlying this connection: the mitochondrial citrate carrier (SLC25A1), a critical regulator of embryonic heart development. Here, using systemic and cardiomyocyte-specific Slc25a1 deletion...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6358c4d-025d-5694-bf78-28f594d4cb9f
DOI: 10.64898/2026.03.06.710200

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cardiomyocyte-intrinsic SLC25A1 regulates cardiac differentiation and mitochondrial functionDOI 10.64898/2026.03.06.710200Read

Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heartSemantic proximity Read

Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytesSemantic proximity Read

Isthmin-1 is a Key Regulator of Induced Pluripotent Stem Cell–Derived Cardiomyocytes Maturation through Activation of p53 SignalingSemantic proximity Read

Multi-omic analysis reveals maturation programs in human pluripotent stem cell-derived cardiomyocytes during long-term cultureSemantic proximity Read

Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1Semantic proximity Read

Molecular Rewiring in TNNT2-Linked Hypertrophic Cardiomyopathy hiPSC-Derived Cardiomyocytes upon Metabolic MaturationSemantic proximity Read

Single‐Cell Atlas of Neonatal Mouse Hearts Reveals an Unexpected CardiomyocyteSemantic proximity Read

Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndromeSemantic proximity Read

The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse.Semantic proximity Read

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organizationSemantic proximity Read

Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channelsSemantic proximity Read

The long and winding road of cardiomyocyte maturation.Semantic proximity Read