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Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes

2021-01-31

Abstract excerpt

<h4>ABSTRACT</h4> A primary limitation in the clinical application of pluripotent stem cell derived cardiomyocytes (PSC-CMs) is the failure of these cells to achieve full functional maturity. In vivo , cardiomyocytes undergo numerous adaptive changes during perinatal maturation. By contrast, PSC-CMs fail to fully undergo these developmental processes, instead remaining arrested at an embryonic stage of maturatio...

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Literature Corpus work
d917925a-cc7d-58d4-9479-edf0610c712d
DOI
10.1101/2021.01.31.428969
Open publication

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Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytesDOI 10.1101/2021.01.31.428969
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