Back to search

Article

An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in <i>Candida albicans</i> during host infection

2025-01-14

Abstract excerpt

Candida albicans (CAL), one of the leading causes of fungal infections affecting nearly 70% of the population, poses a significant global health threat. With the emergence of drug-resistant strains, mortality rates have reached a staggering 63.6% in severe cases, complicating treatment options and demanding the discovery of novel therapeutic targets. To address this pressing need, we employed a unique multidiscipl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e63eb3e8-0294-5a53-a629-1d8cbdd123b7
DOI
10.1101/2025.01.11.632533
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in <i>Candida albicans</i> during host infectionDOI 10.1101/2025.01.11.632533
High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic DifferencesSemantic proximity
<i>Candida auris</i> Metabolism and Growth Preferences in Physiologically Relevant Skin-like ConditionsSemantic proximity
Integrative functional analysis uncovers metabolic differences between Candida speciesSemantic proximity
iCNG99: a validated genome-scale metabolic model of <i>Cryptococcus neoformans strain</i> H99Semantic proximity
Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levelsSemantic proximity
A fungal metabolic regulator underlies infectious synergism during <i>Candida albicans</i> - <i>Staphylococcus</i> aureus intra-abdominal co-infectionSemantic proximity
Integrative functional analysis uncovers metabolic differences between <i>Candida</i> speciesSemantic proximity
<i>Candida auris</i> : multi-omics signature of an emerging and multidrug-resistant pathogenSemantic proximity
Clade delineation and isolate-specific variability of Candida albicans exometabolomeSemantic proximity
Central <i>in vivo</i> mechanisms by which <i>C. difficile’s</i> proline reductase drives efficient metabolism, growth, and toxin productionSemantic proximity
The Transcriptional Stress Response of Candida albicans to Weak Organic AcidsSemantic proximity
Role of Amino Acid Metabolism in the Virulence of Human Pathogenic FungiSemantic proximity
Select a neighboring publication to make it the new centre.