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Cognitive implications and associated transcriptomic signatures of distinct regional iron depositions in cerebral small vessel disease

1 Apr 2025

Abstract excerpt

INTRODUCTION: Regional brain iron dyshomeostasis is observed in cerebral small vessel disease (cSVD) and other neurodegeneration processes. However, its spatial patterns, cognitive impact, and underlying pathological mechanisms remain unclear. METHODS: Voxel-based analysis of quantitative susceptibility mapping (QSM) was used to detect regional susceptibility changes, and their correlations with cognitive...

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PMID: 40257048
DOI: 10.1002/alz.70196

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