Article

Histone H3K36 and H3K27 Modifiers and Readers as Prognostic Factors in Patients with Cancer—A Pancancer Analysis

2023-09-26

Abstract excerpt

Histone modifications, especially H3K27 and H3K36 methylations, are crucial for epigenetic regulation and are often dysregulated in cancer. In a comprehensive analysis of 11,194 patient samples across 32 cancer types, we identified significant genomic alterations in H3K27 and H3K36 modifiers, with the most common being in KDM6B, BRPF1, KDM6A, SETD2, and NSD1. Patients with these alterations also frequently exhibit...

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Literature Corpus work: b618df50-dfa8-5cf7-8b3b-39780f526c97
DOI: 10.20944/preprints202309.1740.v1

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