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Article

Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers.

Epigenetics - 1 Jan 2018

Klein Brianna J, Krajewski Krzysztof, Restrepo Susana, Lewis Peter W, Strahl Brian D, Kutateladze Tatiana G

Abstract excerpt

Histone posttranslational modifications control the organization and function of chromatin. In particular, methylation of lysine 36 in histone H3 (H3K36me) has been shown to mediate gene transcription, DNA repair, cell cycle regulation, and pre-mRNA splicing. Notably, mutations at or near this residue have been causally linked to the development of several human cancers. These observations have helped to...

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Identifiers

PMID: 30045670
DOI: 10.1080/15592294.2018.1503491
PMCID: PMC6224213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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