Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

doi:10.1038/ng.3757

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Article

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

Nature genetics - 1 Feb 2017

Papillon-Cavanagh Simon, Lu Chao, Gayden Tenzin, Mikael Leonie G, Bechet Denise, Karamboulas Christina, Ailles Laurie, Karamchandani Jason, Marchione Dylan M, Garcia Benjamin A, Weinreb Ilan, Goldstein David, Lewis Peter W, Dancu Octavia Maria, Dhaliwal Sandeep, Stecho William, Howlett Christopher J, Mymryk Joe S, Barrett John W, Nichols Anthony C, Allis C David, Majewski Jacek, Jabado Nada

Abstract excerpt

Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs) are deadly and common cancers. Recent genomic studies implicate multiple genetic pathways, including cell signaling, cell cycle and immune evasion, in their development. Here we analyze public data sets and uncover a previously unappreciated role of epigenome deregulation in the genesis of 13% of HPV-negative HNSCCs. Specifically,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28067913
DOI: 10.1038/ng.3757
PMCID: PMC5549104

Genes

NSD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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