Article

A <i>Drosophila</i> model of mitochondrial disease phenotypic heterogeneity

2023-12-05

Abstract excerpt

Mutations in genes that affect mitochondrial function cause primary mitochondrial diseases. Mitochondrial diseases are highly heterogeneous and even patients with the same mitochondrial disease can exhibit broad phenotypic heterogeneity, which is poorly understood. Mutations in subunits of mitochondrial respiratory complex I cause complex I deficiency, which can result in severe neurological symptoms and death in...

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Literature Corpus work: b50d367f-a087-5967-8d6a-2a02bf5f16af
DOI: 10.1101/2023.12.05.570102

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