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Article

Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.

PloS one - 1 Jan 2013

Zhu Jun-Yi, Vereshchagina Natalia, Sreekumar Vrinda, Burbulla Lena F, Costa Ana C, Daub Katharina J, Woitalla Dirk, Martins L Miguel, Krüger Rejko, Rasse Tobias M

Abstract excerpt

Mortalin is an essential component of the molecular machinery that imports nuclear-encoded proteins into mitochondria, assists in their folding, and protects against damage upon accumulation of dysfunctional, unfolded proteins in aging mitochondria. Mortalin dysfunction associated with Parkinson's disease (PD) increases the vulnerability of cultured cells to proteolytic stress and leads to changes in...

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Identifiers

PMID: 24386261
DOI: 10.1371/journal.pone.0083714
PMCID: PMC3875477

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