Back to search

Article

Good response to methotrexate is associated with a decrease in the gene expression of the drug transporter ABCG2 in patients with rheumatoid arthritis

2020-05-15

Abstract excerpt

<title>Abstract</title> <p>Background Methotrexate (MTX) is an anchor drug in the treatment of rheumatoid arthritis (RA). We previously performed a cross-sectional, observational study and reported an association between the gene expression level of the drug transporter ABCG2/BCRP (breast cancer resistance protein) and RA disease control in patients receiving MTX. Methods We designed a prospective study in two me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cfe063a9-ce09-5300-8365-de7bb752f0d2
DOI
10.21203/rs.3.rs-28597/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Good response to methotrexate is associated with a decrease in the gene expression of the drug transporter ABCG2 in patients with rheumatoid arthritisDOI 10.21203/rs.3.rs-28597/v1
Peripheral Blood Gene Expression Signatures Identify Methotrexate Responders in Patients with Rheumatoid ArthritisSemantic proximity
Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted?Semantic proximity
Rheumatoid Arthritis Disease Activity Is Determinant for ABCB1 and ABCG2 Drug-Efflux Transporters FunctionSemantic proximity
Adenosine Deaminase Gene Polymorphism and Baseline Serum Level of Adenosine Deaminase as a Biomarker of Response to Methotrexate in Rheumatoid Arthritis.Semantic proximity
Drug-resistance in rheumatoid arthritis: the role of p53 gene mutations, ABC family transporters and personal factors.Semantic proximity
Can we predict unresponsiveness to methotrexate in rheumatoid arthritis? A pharmacogenetic study.Semantic proximity
Correlation between serum methotrexate-polyglutamate 3 (MTX-PG3) level and disease activity in rheumatoid arthritis patients: A prospective cohort studySemantic proximity
AHR-dependent genes and response to MTX therapy in rheumatoid arthritis patients.Semantic proximity
Role of methotrexate polyglutamation and reduced folate carrier 1 (RFC1) gene polymorphisms in clinical assessment indexes.Semantic proximity
Genetic Polymorphisms in Metabolic and Cellular Transport Pathway of Methotrexate Impact Clinical Outcome of Methotrexate Monotherapy in Japanese Patients with Rheumatoid ArthritisSemantic proximity
Do SNPs in folate pharmacokinetic pathway alter levels of intracellular methotrexate polyglutamates and affect response? A prospective study in Indian patients.Semantic proximity
Preliminary study to identify the predictive factors for the response to methotrexate therapy in patients with rheumatoid arthritis.Semantic proximity
Select a neighboring publication to make it the new centre.