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Article

Mechanisms underlying methotrexate-induced pulmonary toxicity.

Expert opinion on drug safety - 1 Jul 2009

Kim Youn-Jung, Song Mee, Ryu Jae-Chun

Abstract excerpt

BACKGROUND: Methotrexate (MTX) has been widely used for the treatment of inflammatory diseases and rheumatoid arthritis, as well as a variety of tumors. However, MTX-induced pulmonary toxicity is a serious and unpredictable side effect of the therapy, which includes allergic, cytotoxic or immunologic reactions, and is a major clinical problem. OBJECTIVE: To summarize the mechanisms of action involved in...

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Identifiers

PMID: 19538103
DOI: 10.1517/14740330903066734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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