Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line.

doi:10.3109/14397595.2015.1112481

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line.

Modern rheumatology - 1 Jul 2016

Imamura Hitoshi, Yoshina Sawako, Ikari Katsunori, Miyazawa Keiji, Momohara Shigeki, Mitani Shohei

Abstract excerpt

OBJECTIVE: A non-synonymous single nucleotide polymorphism (nsSNP, rs2233434, Val194Ala) in the NFKBIE (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon) gene is known to be a rheumatoid arthritis (RA) susceptibility polymorphism in the Japanese RA population and could be closely associated with nuclear factor kappaB (NF-κB) activity. Inflammation caused by RA is sometimes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to I-kappa B Proteins

Share to Methotrexate

Share to NF-kappa B

Share to Proto-Oncogene Proteins

Share to Reduced Folate Carrier Protein

Share to Synovial Membrane

Source

Open in PubMed Open full text

Identifiers

PMID: 26587663
DOI: 10.3109/14397595.2015.1112481
PMCID: PMC4898165

Genes

NFKBIE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line.PMID 26587663Read ↗

Methotrexate Inhibits NF‐κB Activity Via Long Intergenic (Noncoding) RNA–p21 InductionSemantic proximity Read ↗

Low dose methotrexate impaired T cell transmigration through down-regulating CXCR4 expression in rheumatoid arthritisSemantic proximity Read ↗

Influence of RFC1 c.80A>G Polymorphism on Methotrexate-Mediated Toxicity and Therapeutic Efficacy in Rheumatoid Arthritis: A Meta-analysis.Semantic proximity Read ↗

Role of Caveolin 1, E-Cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cellsSemantic proximity Read ↗

Transcription regulatory polymorphism -43T>C in the 5'-flanking region of SLC19A1 gene could affect rheumatoid arthritis patient response to methotrexate therapy.Semantic proximity Read ↗

The association between reduced folate carrier-1 gene 80G/A polymorphism and methotrexate efficacy or methotrexate related-toxicity in rheumatoid arthritis: A meta-analysis.Semantic proximity Read ↗

Association between SLCO1A2 genetic variation and methotrexate toxicity in human rheumatoid arthritis treatment.Semantic proximity Read ↗

A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis.Semantic proximity Read ↗

Methotrexate Transport and ResistanceSemantic proximity Read ↗

Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians.Semantic proximity Read ↗

Mechanisms underlying methotrexate-induced pulmonary toxicity.Semantic proximity Read ↗

MiR-595 Suppresses the Cellular Uptake and Cytotoxic Effects of Methotrexate by Targeting SLC19A1 in CEM/C1 Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.