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Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis

12 Apr 2021

Abstract excerpt

Eotaxin-1 (CCL11) induces the migration of different leukocyte types by interacting with CCR3. In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) are pathogenic effectors and a major CCR3-expressing cell. The aim of this study was to investigate the expression and function of CCL11 in RA FLS. The expression of CCL11 and CCR3 was evaluated by ELISA, immunofluorescence and quantitative PCR analysis....

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PMID: 33846499
DOI: 10.1038/s41598-021-87199-7

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