Article

Engineering lung-sensing T cells using synthetic receptors targeting RAGE

2025-06-07

Abstract excerpt

Our goal was to leverage synthetic biology approaches to engineer lung-sensing T cells that trigger synthetic transcriptional programs only when in the lung. First, we identified a lung-specific cell surface protein, receptor for advanced glycation endproducts (RAGE), expressed at high levels exclusively in the lung. Then, we engineered chimeric antigen receptors (CAR) and synthetic notch receptors (SynNotch) to b...

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Literature Corpus work: 4700a3f2-d98b-53e4-819f-e6376b495de4
DOI: 10.1101/2025.06.06.658315

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