Article

Fluorescein-Based SynNotch Adaptors for Regulating Gene Expression Responses to Diverse Extracellular Cues

2024-06-12

Abstract excerpt

<h4>ABSTRACT</h4> We introduce an adaptor-based strategy for regulating fluorescein-binding synthetic Notch (SynNotch) receptors using ligands based on conjugates of fluorescein isomers and analogs. To develop a versatile system, we evaluated the surface expression and activities of multiple constructs containing distinct extracellular fluorescein-binding domains. Using an optimized receptor, we devised ways to r...

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Literature Corpus work: 5f9bc830-cdd4-5194-9cfe-aaf652bce7ca
DOI: 10.1101/2024.06.12.598538

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