Article

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates

2025-05-27

Abstract excerpt

<h4>Summary</h4> TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We showed that NAP1 condensates concentrate TBK1. Using NAP1 KO cell lines, we discovered that NAP1 exerts a dual effect on TBK1 activity. Initially, NAP1 binds TBK1 and increases its activity, which enha...

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Literature Corpus work: b5a5e954-cc4b-5fc4-9607-8aa026484faf
DOI: 10.1101/2025.05.21.655319

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