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Article

Human TBK1: A Gatekeeper of Neuroinflammation.

Trends in molecular medicine - 1 Jun 2016

Ahmad Liyana, Zhang Shen-Ying, Casanova Jean-Laurent, Sancho-Shimizu Vanessa

Abstract excerpt

The importance of TANK binding kinase-1 (TBK1), a multimeric kinase that modulates inflammation and autophagy, in human health has been highlighted for the first time by the recent discoveries of mutations in TBK1 that underlie amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), normal tension glaucoma (NTG) or childhood herpes simplex encephalitis (HSE). Gain-of-function of TBK1 are associated...

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Source

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Identifiers

PMID: 27211305
DOI: 10.1016/j.molmed.2016.04.006
PMCID: PMC4890605

Genes

TBK1
TANK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Human TBK1: A Gatekeeper of Neuroinflammation.PMID 27211305Read ↗

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