Article

Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G

2026-02-19

Abstract excerpt

Human Leukocyte Antigen (HLA)-G is selectively expressed by fetal trophoblast cells that invade maternal tissue and encounter maternal natural killer (NK) cells early in pregnancy. In NK cells, the endosomal receptor KIR2DL4 responds to soluble HLA-G by inducing a broad transcriptional program to support placental development. Structural features of KIR2DL4 that control ligand binding and endocytosis are unclear....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b57dbc31-95d3-5005-b357-58a5feb307a7
DOI: 10.64898/2026.02.18.706601

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-GDOI 10.64898/2026.02.18.706601Read

KIR2DL4 (CD158d): An activation receptor for HLA-GSemantic proximity Read

Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.Semantic proximity Read

The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4Semantic proximity Read

NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain.Semantic proximity Read

Residues Met76 and Gln79 in HLA-G alpha1 domain involve in KIR2DL4 recognition.Semantic proximity Read

The Molecular and Functional Characteristics of HLA-G and the Interaction with Its Receptors: Where to Intervene for Cancer Immunotherapy?Semantic proximity Read

Roles of HLA-G/KIR2DL4 in Breast Cancer Immune MicroenvironmentSemantic proximity Read

Inhibitory NK Receptor Recognition of HLA-G: Regulation by Contact Residues and by Cell Specific Expression at the Fetal-Maternal InterfaceSemantic proximity Read

KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.Semantic proximity Read

Immune modulation of HLA‐G dimer in maternal‐fetal interfaceSemantic proximity Read

Peptide-specific engagement of the activating NK cell receptor KIR2DS1.Semantic proximity Read

Structural Studies on HLA-G: Implications for Ligand and Receptor BindingSemantic proximity Read