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Article

Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment

3 Feb 2022

Abstract excerpt

Human leukocyte antigen (HLA)-G is a nonclassical MHC Class I molecule, which was initially reported as a mediator of immune tolerance when expressed in extravillous trophoblast cells at the maternal-fetal interface. HLA-G is the only known ligand of killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), an atypical family molecule that is widely expressed on the surface of NK cells. Unlike other KIR receptors,...

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PMID: 35185887
DOI: 10.3389/fimmu.2022.791975

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