Article
Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.
The Journal of biological chemistry - 14 Apr 2006
Shiroishi Mitsunori, Kuroki Kimiko, Ose Toyoyuki, Rasubala Linda, Shiratori Ikuo, Arase Hisashi, Tsumoto Kouhei, Kumagai Izumi, Kohda Daisuke, Maenaka Katsumi
Abstract excerpt
HLA-G is a nonclassical major histocompatibility complex class I (MHCI) molecule, which is expressed in trophoblasts and confers immunological tolerance in the maternal-fetal interface by binding to leukocyte Ig-like receptors (LILRs, also called as LIR/ILT/CD85) and CD8. HLA-G is expressed in disulfide-linked dimer form both in solution and at the cell surface. Interestingly, MHCI dimer formations have been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.