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Article

NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain.

International journal of molecular sciences - 19 Jun 2020

Hò Gia-Gia T, Celik Alexander A, Huyton Trevor, Hiemisch Wiebke, Blasczyk Rainer, Simper Gwendolin S, Bade-Doeding Christina

Abstract excerpt

Natural killer (NK) cell therapies are a tool to antagonize a dysfunctional immune system. NK cells recognize malignant cells, traffic to a tumor location, and infiltrate the solid tumor. The immune checkpoint molecule human leukocyte antigen (HLA)-G is upregulated on malignant cells but not on healthy surrounding cells, the requirement of understanding the basis of receptor mediated events at the HLA-G/NK cell...

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Identifiers

PMID: 32575403
DOI: 10.3390/ijms21124362
PMCID: PMC7352787

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