Article

Single-cell Transcriptomic Profiling of Pancreatic Ductal Adenocarcinoma: Epithelial Reprogramming and Systemic Immune Exhaustion

2025-11-12

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human malignancies, with a five-year survival rate below 10%, underscoring the urgent need to unravel its complex pathophysiology. In this study, we employ an integrative single-cell RNA sequencing (scRNA-seq) approach to comprehensively characterize both the pancreatic tumor microenvironment and peripheral blood mononuclear cells (PBMCs) from...

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Literature Corpus work: b57b3de7-7846-5407-8882-26e864db5be9
DOI: 10.1101/2025.11.10.687730

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