Article
Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic Aβ Peptides.
Molecular neurobiology - 1 Nov 2022
Hanbouch Linda, Schaack Béatrice, Kasri Amal, Fontaine Gaëlle, Gkanatsiou Eleni, Brinkmalm Gunnar, Camporesi Elena, Portelius Erik, Blennow Kaj, Mourier Gilles, Gilles Nicolas, Millan Mark J, Marquer Catherine, Zetterberg Henrik, Boussicault Lydie, Potier Marie-Claude
Abstract excerpt
Excess brain cholesterol is strongly implicated in the pathogenesis of Alzheimer's disease (AD). Here we evaluated how the presence of a cholesterol-binding site (CBS) in the transmembrane and juxtamembrane regions of the amyloid precursor protein (APP) regulates its processing. We generated nine point mutations in the APP gene, changing the charge and/or hydrophobicity of the amino-acids which were previously...
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