Article

Specific mutations in the cholesterol-binding site of APP alter its processing and favor the production of shorter, less toxic Aβ peptides.

2022-04-27

Abstract excerpt

<title>Abstract</title> <p>Excess brain cholesterol is strongly implicated in the pathogenesis of Alzheimer disease (AD). Here we evaluated how the presence of a cholesterol-binding site (CBS) in the transmembrane and juxtamembrane regions of the amyloid precursor protein (APP) regulates its processing.We generated nine point mutations in the <italic>APP</italic> gene, changing the charge and/or hydrophobicity of...

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Literature Corpus work: f46f6d34-0c08-5b86-a4ce-997ffdef0cce
DOI: 10.21203/rs.3.rs-1574121/v1

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