Article

Pfs48/45 nanobodies block <i>Plasmodium falciparum</i> transmission

2025-04-25

Abstract excerpt

Malaria parasite fertilisation occurs within the Anopheles mosquito midgut. Interventions that inhibit parasite fertilisation prevent ongoing transmission and are important for malaria elimination efforts. Pfs48/45 and Pfs230 are two leading transmission-blocking vaccine candidates. Both proteins form a complex on the surface of sexual stage parasites and are essential for male fertility. Here we have identified...

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Identifiers and source

Literature Corpus work: b55e9639-da1c-520e-babb-565558f29992
DOI: 10.1101/2025.04.24.650534

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