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Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody

12 Dec 2023

Abstract excerpt

Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that block Plasmodium parasite development in the mosquito midgut, thus preventing mosquitoes from becoming infectious. While the Pro-domain and first of fourteen 6-Cysteine domains (Pro-D1) of the Plasmodium gamete surface protein Pfs230 are known targets of transmission-blocking antibodies, no studies to date have discovered other Pfs230...

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PMID: 38086855
DOI: 10.1038/s41541-023-00784-x

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