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A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes

19 Mar 2021

Abstract excerpt

Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gamete surface protein Pfs230, a key protein in sexual stage development of P. falciparum parasites. Among nine Pfs230 human monoclonal antibodies (mAbs) that we generated, one potently blocks transmission to...

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PMID: 33741942
DOI: 10.1038/s41467-021-21955-1

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