Article
G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.
Human molecular genetics - 1 Jan 2018
Nguyen An Phu Tran, Daniel Guillaume, Valdés Pamela, Islam Md Shariful, Schneider Bernard L, Moore Darren J
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). LRRK2 mutations typically give rise to Lewy pathology in the brains of PD subjects yet can induce tau-positive neuropathology in some cases. The pathological interaction between LRRK2 and tau remains poorly defined. To explore this interaction in vivo, we crossed a well-characterized human...
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