Article

Disulfiram Attenuates Paraquat-Induced Renal Injury and Fibrosis Associated with Modulation of Smad3/Smad7 Expression

2026-07-14

Abstract excerpt

<title>Abstract</title> <p>Purpose Paraquat (PQ) herbicide induces nephrotoxicity characterized by oxidative stress and fibrosis, contributing to chronic kidney disease. Drug repurposing offers a strategic approach for rapid therapeutic development. This study evaluated the nephroprotective potential of disulfiram (DSF), a clinically approved agent with emerging antioxidant and antifibrotic properties, against P...

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Literature Corpus work: b5148958-5cbb-56de-8327-bf249c36d5ae
DOI: 10.21203/rs.3.rs-10145851/v1

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Disulfiram Attenuates Paraquat-Induced Renal Injury and Fibrosis Associated with Modulation of Smad3/Smad7 ExpressionDOI 10.21203/rs.3.rs-10145851/v1Read

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