Elucidation of Puberulic Acid–Induced Nephrotoxicity Using Stem Cell-based Kidney Organoids

Abstract excerpt

<h4>Background and hypothesis</h4> Recent cases of acute kidney injury (AKI) in Japan have been linked to the Beni-koji CholesteHelp supplement. Renal biopsies from affected patients revealed tubular damage, and puberulic acid was subsequently identified as a potential nephrotoxic contaminant. Recognizing the urgent need for a reliable in vitro nephrotoxicity testing platform, we hypothesized that a kidney organo...

Topics

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• 3D Printing in Biomedical Research
• Biomedical Ethics and Regulation
• Birth, Development, and Health
• Chemotherapy-induced organ toxicity mitigation
• Drug-Induced Hepatotoxicity and Protection
• Organ Donation and Transplantation
• Pluripotent Stem Cells Research
• Renal and related cancers

Identifiers and source

Literature Corpus work

cb50ea22-741d-5a32-b2da-167e2f311579

DOI

10.1101/2025.04.30.651410