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Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis

7 Jan 2025

Abstract excerpt

Renal fibrosis is the most common pathway for the development of end-stage renal disease (ESRD) in various kidney diseases. Currently, the treatment options for renal fibrosis are limited. Ferroptosis is iron-mediated lipid peroxidation, triggered mainly by iron deposition and ROS generation. Notably, the kidney is the most sensitive of all tissues to iron-dependent ferroptosis, and the inhibition of ferroptosis...

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PMID: 39764683
DOI: 10.1002/ptr.8425

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