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Linking PFOS exposure to chronic kidney disease: A multimodal study integrating epidemiology, network toxicology, and experimental validation

29 Jul 2025

Abstract excerpt

Perfluorooctane sulfonate (PFOS), a widely used persistent organic pollutant, has been implicated in multiple toxicities. However, its nephrotoxic mechanisms remain unclear. Chronic kidney disease (CKD) is a growing global health concern. We adopted a multidisciplinary approach combining epidemiological analysis, network toxicology, molecular docking, and animal experiments to investigate PFOS-induced kidney...

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PMID: 40737851
DOI: 10.1016/j.ecoenv.2025.118770

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