Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer.

doi:10.1038/s41591-018-0019-5

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Article

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer.

Nature medicine - 1 Jul 2018

Lissanu Deribe Yonathan, Sun Yuting, Terranova Christopher, Khan Fatima, Martinez-Ledesma Juan, Gay Jason, Gao Guang, Mullinax Robert A, Khor Tin, Feng Ningping, Lin Yu-Hsi, Wu Chia-Chin, Reyes Claudia, Peng Qian, Robinson Frederick, Inoue Akira, Kochat Veena, Liu Chang-Gong, Asara John M, Moran Cesar, Muller Florian, Wang Jing, Fang Bingliang, Papadimitrakopoulou Vali, Wistuba Ignacio I, Rai Kunal, Marszalek Joseph, Futreal P Andrew

Abstract excerpt

Lung cancer is a devastating disease that remains a top cause of cancer mortality. Despite improvements with targeted and immunotherapies, the majority of patients with lung cancer lack effective therapies, underscoring the need for additional treatment approaches. Genomic studies have identified frequent alterations in components of the SWI/SNF chromatin remodeling complex including SMARCA4 and ARID1A. To...

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PMID: 29892061
DOI: 10.1038/s41591-018-0019-5
PMCID: PMC6650267

Genes

SMARCA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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