Article

In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury

2023-12-07

Abstract excerpt

<h4>Summary</h4> Z-lines are core ultrastructural organizers of cardiomyocytes that modulate many facets of cardiac pathogenesis. Yet a comprehensive proteomic atlas of Z-line-associated components remain incomplete. Here, we established an adeno-associated virus (AAV)-delivered, cardiomyocyte-specific, proximity-labeling approach to characterize the Z-line proteome in vivo. We found palmdelphin (PALMD) as a nove...

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Literature Corpus work: b5126f11-be85-5fc0-a31f-6efa0581702b
DOI: 10.1101/2023.12.06.570334

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In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injuryDOI 10.1101/2023.12.06.570334Read

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