Article
Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.
Journal of cellular physiology - 1 Jan 2017
Bang Marie-Louise
Abstract excerpt
The cardiac Z-line at the boundary between sarcomeres is a multiprotein complex connecting the contractile apparatus with the cytoskeleton and the extracellular matrix. The Z-line is important for efficient force generation and transmission as well as the maintenance of structural stability and integrity. Furthermore, it is a nodal point for intracellular signaling, in particular mechanosensing and...
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