Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload.

doi:10.7554/eLife.58313

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload.

eLife - 24 Sept 2021

Filomena Maria Carmela, Yamamoto Daniel L, Carullo Pierluigi, Medvedev Roman, Ghisleni Andrea, Piroddi Nicoletta, Scellini Beatrice, Crispino Roberta, D'Autilia Francesca, Zhang Jianlin, Felicetta Arianna, Nemska Simona, Serio Simone, Tesi Chiara, Catalucci Daniele, Linke Wolfgang A, Polishchuk Roman, Poggesi Corrado, Gautel Mathias, Bang Marie-Louise

Abstract excerpt

Myopalladin (MYPN) is a striated muscle-specific immunoglobulin domain-containing protein located in the sarcomeric Z-line and I-band. MYPN gene mutations are causative for dilated (DCM), hypertrophic, and restrictive cardiomyopathy. In a yeast two-hybrid screening, MYPN was found to bind to titin in the Z-line, which was confirmed by microscale thermophoresis. Cardiac analyses of MYPN knockout (MKO) mice showed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Dilated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connectin

Share to Muscle Proteins

Share to Mutant Proteins

Share to Myocytes, Cardiac

Share to Pressure

Share to Sarcomeres

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 34558411
DOI: 10.7554/eLife.58313
PMCID: PMC8547954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload.PMID 34558411Read ↗

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations.Semantic proximity Read ↗

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac PhenotypesSemantic proximity Read ↗

Functional and Expression Studies of iPSC-Derived Cardiomyocytes Carrying a Novel HCM-Associated MYPN Genetic VariantSemantic proximity Read ↗

Unveiling cellular mechanisms underlying MYZAP related dilated cardiomyopathy using patient specific hiPSC cardiomyocytes.Semantic proximity Read ↗

Cardiomyopathy-associated and basic residue mutations in myopalladin alter actin binding, bundling, and structural stability.Semantic proximity Read ↗

Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy.Semantic proximity Read ↗

Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalitiesSemantic proximity Read ↗

The role of the M-band myomesin proteins in muscle integrity and cardiac diseaseSemantic proximity Read ↗

Identification of <i>MYOM2</i> as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot and its functional evaluation in the <i>Drosophila</i> heartSemantic proximity Read ↗

A ZASP Missense Mutation, S196L, Leads to Cytoskeletal and Electrical Abnormalities in a Mouse Model of CardiomyopathySemantic proximity Read ↗

Roles of Nebulin Family Members in the Heart.Semantic proximity Read ↗

Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.