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Article

Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis

19 Jun 2019

Abstract excerpt

Atrial dysfunction is highly prevalent and associated with increased severity of heart failure. While rapid excitation-contraction coupling depends on axial junctions in atrial myocytes, the molecular basis of atrial loss of function remains unclear. We identified approximately 5-fold lower junctophilin-2 levels in atrial compared with ventricular tissue in mouse and human hearts. In atrial myocytes, this...

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PMID: 31217359
DOI: 10.1172/jci.insight.127116

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