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Decoding the JAK-STAT axis in colorectal cancer with AI-HOPE-JAK-STAT: A conversational artificial intelligence approach to clinical-genomic integration

2025-06-09

Abstract excerpt

<h4>Background/Objective</h4> The Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway is a critical mediator of immune regulation, inflammation, and cancer progression. Although implicated in colorectal cancer (CRC) pathogenesis, its molecular heterogeneity and clinical significance remain insufficiently characterized—particularly within early-onset CRC (EOCRC) and across div...

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Literature Corpus work
a4b0eea0-2343-5256-8c46-f88c8ea3e09b
DOI
10.1101/2025.06.08.25329216
Open publication

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