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AI-HOPE-TGFbeta: A Conversational AI Agent for Integrative Clinical and Genomic Analysis of TGF-β Pathway Alterations in Colorectal Cancer to Advance Precision Medicine

2025-05-21

Abstract excerpt

<h4>Introduction</h4> Early-onset colorectal cancer (EOCRC) is rising rapidly, particularly among Hispanic/Latino (H/L) populations, who face disproportionately poor outcomes. The TGF-β signaling pathway plays a critical role in colorectal cancer (CRC) progression by mediating epithelial-to-mesenchymal transition (EMT), immune evasion, and metastasis. However, integrative analyses linking TGF-β alterations to clin...

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Literature Corpus work
c2183fbc-441c-5404-bc2a-a9d960c06cc2
DOI
10.1101/2025.05.20.25327967
Open publication

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