Article

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases

2024-05-29

Abstract excerpt

<h4>SUMMARY</h4> All eukaryotes share a single-celled ancestor from ∼1.5–1.8 billion years ago, the Last Eukaryotic Common Ancestor (LECA). Roughly half of gene families found in modern eukaryotes were already present in LECA, forming molecular systems that continue to influence genetic diseases and traits today. To investigate these systems, we compared genes across 156 organisms to define a core set of protein-...

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Literature Corpus work: b4f6a20d-8654-570e-9db6-0b6c2bf7a5a6
DOI: 10.1101/2024.05.26.595818

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