Back to search

Article

A multilayer network approach elucidates time- and tissue-specific developmental and aging processes

2025-05-08

Abstract excerpt

Understanding the dynamic interplay of proteins across different life stages and tissues is essential for deciphering the molecular mechanisms underpinning development, aging, and disease. Here, we present a comprehensive network-based framework that constructs and integrates 119 time- and tissue-specific protein-protein interaction (PPI) networks derived from transcriptomic data, offering insights into proteomic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
34f5c83c-280e-5c4c-8995-883398eab845
DOI
10.1101/2025.05.02.651926
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A multilayer network approach elucidates time- and tissue-specific developmental and aging processesDOI 10.1101/2025.05.02.651926
The molecular landscape of premature aging diseases defined by multilayer network explorationSemantic proximity
Sample-specific protein-protein interaction networks inferred from transcriptomics and proteomics show high similaritiesSemantic proximity
The analyses of human inherited disease and tissue-specific proteins in the interaction network.Semantic proximity
Plasma proteomic profile of age, health span, and all‐cause mortality in older adultsSemantic proximity
A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseasesSemantic proximity
An integrated resource for systems-level analysis of aging hallmarks and associated genesSemantic proximity
Ageing Transcriptome Meta-Analysis Reveals Similarities Between Key Mammalian TissuesSemantic proximity
Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and RejuvenationSemantic proximity
The signaling hubs at the crossroad of longevity and age-related disease networksSemantic proximity
An analysis of aging-related genes derived from the Genotype-Tissue Expression project (GTEx)Semantic proximity
Deciphering hallmark processes of aging from interaction networks.Semantic proximity
A modular architecture of human cellular aging across organs and diseasesSemantic proximity
Select a neighboring publication to make it the new centre.