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Article

A human phenome-interactome network of protein complexes implicated in genetic disorders.

Nature biotechnology - 1 Mar 2007

Lage Kasper, Karlberg E Olof, Størling Zenia M, Olason Páll I, Pedersen Anders G, Rigina Olga, Hinsby Anders M, Tümer Zeynep, Pociot Flemming, Tommerup Niels, Moreau Yves, Brunak Søren

Abstract excerpt

We performed a systematic, large-scale analysis of human protein complexes comprising gene products implicated in many different categories of human disease to create a phenome-interactome network. This was done by integrating quality-controlled interactions of human proteins with a validated, computationally derived phenotype similarity score, permitting identification of previously unknown complexes likely to...

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PMID: 17344885
DOI: 10.1038/nbt1295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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